Word: vascularized
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Other researchers are zeroing in on different targets. Some are looking at a specialized growth factor called VEGF (for vascular endothelial growth factor) that so far has been found only in the blood vessels that feed tumors. One synthetic molecule being tested at UCLA prevents VEGF from stimulating new growth by elbowing it aside and taking its place in the cell's receptors. Safety studies in more than 30 patients have so far not revealed any major side effects, although their tumors' growth was only slowed, not halted. Dr. Joseph Sparano, at Montefiore Medical Center in New York City...
...reluctant to return their leftover pills. The medication works by suppressing the effect of the naturally occurring enzyme phosphodiesterase type 5 (PDE5), which causes an erection to subside after orgasm by breaking down the body chemical known as cyclic GMP. It is cyclic GMP that initiates the muscular and vascular changes that lead to an erection in the first place. While PDE5 is always present in the penis, cyclic GMP is produced only during arousal. The catch in impotent men is that they may not produce enough cyclic GMP to temporarily "win out" over the PDE5. Thus the efficacy...
Jessica's zest for life is something mother imparted to daughter. Since she was seven, Jessica had witnessed her plucky mom battle angiosarcoma (cancer of the vascular system), which claimed her life 14 days after Jessica's interview with Time. Patty cherished life, says Tackett, and in that way "Jessica is so much like her." --Reported by Leslie Everton Brice/Conyers...
Ordinarily pretty harmless stuff, homocysteine is used by the body to help manufacture proteins and carry out cellular metabolism. Too much of it, however, appears to cause blood platelets to clump together and vascular walls to begin to break down. In older patients, a lifetime of this damage may give arteries the scarred and thickened texture that provides circulating cholesterol with a place to stick and grow. In the young boy, accelerated homocysteine production caused by a genetic defect apparently led to accelerated damage. In both instances, however, McCully points to the same chemical culprit. "The underlying cause of heart...
...center. I thought it was unconscionable for the hospital to distribute scrip for the patients to obtain free cigarettes in the hospital commissary while nurses administered chemotherapy to cancer patients who smoked. Patients were grotesquely disfigured by the surgical removal of facial cancers or had legs amputated because of vascular disease caused by cigarette addiction. Many of these veterans told me their first cigarettes were courtesy of the military while they were in the service. How ironic that war did not maim or kill these men but that cigarettes did and will. NORA MARTIN VETTO Phoenix, Ariz...