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...heart-patient trial, St. Elizabeth's Isner found a novel way around the delivery problem. Eschewing virus carriers, he fashioned a construct called "naked DNA." It consists of part of a human gene called VEG-F, which stimulates the growth of blood vessels, and includes its signal segments. These segments, Isner explains, "order the cell, once it has manufactured the gene product, to export it from the cell...

Author: /time Magazine | Title: Fixing the Genes | 1/11/1999 | See Source »

...does the naked DNA, without viral assistance, penetrate the walls of the heart-muscle cells? "To be perfectly honest," Isner confesses, "no one really understands how it gets there." But unlike most other therapeutic genes, which must find their way into millions of cells to have a therapeutic effect, VEG-F needs to invade only relatively few. Its protein product, issuing from the cell, can act on untold numbers of surrounding, untreated cells. Quips Isner in a parody of the Marine Corps slogan, "All we're looking for are a few good cells...

Author: /time Magazine | Title: Fixing the Genes | 1/11/1999 | See Source »

...residents of Indianola so the folks watching the news can see him talking to Iowa farmers (two-thirds of whom were college students bused in from Ohio to give the event a shot of adrenaline). It has all the authenticity of an infomercial audience whooping it up for the Veg-O-Matic at two o'clock in the morning...

Author: /time Magazine | Title: MOB SCENE | 3/4/1996 | See Source »

...U.f.orb. It is really a mini-album, a sort of appetizer to Orb's new follow-up full-length album. Orb really takes on the metaphor of appetizer, calling the album Pomme Fritz, and naming some of the tracks after English pub food--"Pomme Fritz (Meat 'n Veg)," "More Gills Less Fishcakes," and "Bang 'er 'n Chips...

Author: By Joel Villasenor-ruiz, | Title: Entranced by the Beat | 4/20/1995 | See Source »

...bigger and more aggressive packaged-food industry. It pits a handful of exercise machines against a century of labor-saving devices. It pits a frenetic workaday pace against the understandable temptation to put one's feet up at the end of the day, turn on the tube and just veg out. It may even turn out that the best-intentioned resolutions made in the '80s -- to lose weight, to eat "lite," to plunge headlong into heart-pounding aerobics -- ended up doing more harm than good...

Author: /time Magazine | Title: Fat Times What health craze? | 1/16/1995 | See Source »

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