Word: verma
(lookup in dictionary)
(lookup stats)
Dates: all
Sort By: most recent first
(reverse)
...Olivia Verma '00 also attended last year'sSpringfest and said going into the alcohol "cage"made her feel like a criminal. This year she saidshe barely noticed its absence...
...agree that the adenovirus and retrovirus vectors are imperfect, to say the least. In addition to having immunological side effects, both lack the carrying capacity to accommodate the larger, more complex genes that would be useful in therapy. "There are only three problems in gene therapy," says Salk's Verma, "delivery, delivery and delivery. It isn't going to be a problem to make gene therapy work--if we have an appropriate set of tools to deliver the genes...
...other new vector is being fashioned by Salk's Verma. "What we want," he says, "is a virus that is easy to make, that delivers genes at very high efficiency, that can infect a nondividing cell and that enables its therapeutic gene to become part and parcel of the chromosome...
Seeking the best candidate, Verma zeroed in on the most notorious of the retroviruses--HIV, the virus that causes AIDS. He eliminated the protein envelope that allows the virus entry into T cells, substituted one enabling it to infect a greater variety of cells, and removed the six genes that make the virus dangerous...
...lentivirus, as Verma dubbed his creation, ever recombine to generate a virus that has the ability to cause disease? "We have done 115 such preparations," he says reassuringly, "and to date we have never seen a virus that is capable of infecting new cells." Later this year he plans to ask the FDA for permission to begin a Phase I trial for hemophilia...