Word: vertex
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Dates: during 1990-1999
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...Cambridge firms, Millennium Pharmaceuticals and Vertex Pharmaceuticals, have been at the forefront of the second technological revolution...
...Vertex, founded by a Harvard graduate in 1989, is a pioneer in "structure-based drug design." In theory, the idea is plausible enough: if one knows the precise three-dimensional structure of an enzyme target, one can use a computer to design a perfectly complementary "small molecule drug" to jam into the enzyme and disable it, just as a locksmith can build a key from scratch to open a lock...
...Vertex's first major research effort--designing a safe and reliable inhibitor for the HIV protease that assists with the replication of the HIV virus--started with generating a molecular map of the protease enzyme...
Barber: Ah, but the study also says that only a bald spot on top - so-called vertex baldness - is the problem. If you're losing hair in front or on the sides, you're probably...