Word: vioxx
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Dates: during 2000-2009
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CLEARED. MERCK, multinational drugmaker; of responsibility for the death of Richard Irvin, a Florida man who had a fatal heart attack after taking the company's painkiller Vioxx for less than a month; in a federal court in New Orleans. Merck faces more than 9,500 lawsuits over the drug, which it pulled in 2004. The victory was Merck's first in federal court, following a loss and a win in state-court trials last year...
...meeting took an unexpected turn when cardiologist Steven Nissen of the Cleveland Clinic made a motion for a black box warning. Dr. Nissen, who was among the early warners on the risks of the now-withdrawn arthritis drug Vioxx, was concerned that the 25 cases might be just the tip of an iceberg. "There's no mandatory reporting of these cases," he says. He notes that the stimulants in question are known to raise blood pressure and heart rate. "Raising blood pressure of a child or adult continuously over many years worries me," Nissen told TIME. "There is a linear...
...other psychiatrists point out that unlike Vioxx, Ritalin is a drug with a 50 year history. Says Dr. Hallowell, "I have never had a patient suffer a lethal side effect nor anything close to it. I have had to discontinue the medication, perhaps once out of every 10 times I prescribe it, due to side effects," which include weight loss, insomnia, tics and twitches, and personality changes. "These meds are far from perfect," says Hallowell, "but they are the best medication option we have and are very safe when used correctly...
...been a painful 15 months both for people with arthritis and for the companies that make their painkilling drugs. The once high-flying anti-inflammatories known as cox-2 inhibitors nearly crashed and burned in September 2004, when Merck's popular Vioxx was pulled from the market after a study revealed it could raise the risk of heart attack and stroke. A competitor made by Pfizer, Bextra, was yanked some months later, leaving only Pfizer's Celebrex behind-and a new, required safety warning hasn't exactly done wonders for that drug's appeal. Celebrex sales are off more than...
...Pfizer's move is a dramatic one, but it's also an important one-and not just for Big Pharma's balance sheets. In the wake of the Vioxx withdrawal, many arthritis sufferers have turned to drugs in the ibuprofen and naproxen families, such as Advil and Aleve. But earlier this year the Food and Drug Administration (FDA) announced that those drugs may also carry cardiovascular risks; in any event, for some people they just don't pack the same pain-relieving punch. Others patients are relying on oxycontin and morphine-based medications, which may not endanger the cardiovascular system...