Word: vioxx
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...VIOXX...
...Estimated number of Vioxx users in the U.S. who because of safety concerns switched to another drug within 24 hours of Merck's announcing its Vioxx recall...
More broadly, the news about Vioxx shows once again why it is so important to continue to monitor the safety of a medication even after it has been approved. Most clinical studies involve only a few thousand patients and may last less than a year--enough to catch major problems. But once a drug passes muster with the FDA, it is often prescribed for millions of people. That's when more subtle side effects may emerge. Unfortunately, so-called postapproval surveillance still tends to get short shrift...
...real world, where someone might suffer from arthritis and heart disease and stomach problems all at once. Figuring out which drugs truly are safe and effective--and under what circumstances--is bound to become more complex as the population ages and more medications are developed for chronic conditions. Vioxx may be the biggest withdrawal of a drug in years, but it won't be the last. --With reporting by Unmesh Kher/New York
Withdrawal Pains Why Vioxx was yanked off pharmacy shelves...