Word: viruses
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Dates: during 1980-1989
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...gene transplants come in. Anderson has developed a technique using a "marker" that will let Rosenberg follow the progress of the TILs. The marker is the E. coli gene that makes a cell resistant to the antibiotic neomycin. Anderson has been able to tuck that bacterial gene into a virus and then implant the virus into TILs. Once inside the TILs, the gene becomes fully functional...
...genes that will enable their bodies to mass-produce such anticancer agents as interleukin-2 and tumor necrosis factor. Anderson believes the day is not far off when it will be possible to transplant a gene containing instructions for the manufacture of CD4, a substance that combats the AIDS virus. Ultimately, researchers think they may be able to conquer some hereditary diseases by replacing defective genes with normal ones...
...goal is to find a dose of ddC high enough to stop the virus from growing, but low enough not to cause nerve damage," Schooley added...
...recently published articles, one team said it has tested a substance--known as dideoxycytidine (ddC)--that appears to be more effective and less toxic than AZT, the drug now used to treat the virus. A second team is conducting experiments on a new version of Soluble t4, a drug that slows the spread of the AIDS virus in the body...
...affiliation with three other scientists around the country, Assistant Professor of Medicine Robert T. Schooley and his colleagues concluded in an article published this month in the Annals of Internal Medicine that ddC, which in many ways resembles the FDA-approved AZT, deters the replication of the AIDS virus in humans...