Word: vogelstein
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...genes responsible for at least two types of hereditary colon cancer--dubbed FAP and HNPCC --that trigger malignant growths in folks in their 30s and 40s. But it can be tough to tell who has the genes, since they are often camouflaged by normal ones. Last month Dr. Bert Vogelstein and his colleagues at Johns Hopkins Medical School in Baltimore, Md., reported in the journal Nature that they have figured out how to unmask the defective genes. Meanwhile, researchers at Exact Laboratories in Maynard, Mass., have developed a simple stool test that will alert your doctor to any dangerous genetic...
...killer. Three decades ago, the Federal Government's "War on Cancer" underwrote basic discoveries about the ways broken-down genes lead to malignancies. Now that work is beginning to pay off. "The black box that was the cancer cell has been opened," says Dr. Bert Vogelstein, a world-renowned investigator of cancer genes at the Johns Hopkins University in Baltimore, Md. "As researchers, we feel a tremendous amount of hope, probably for the first time in the history of cancer treatment...
...people in the U.S. this year. Rather, the optimism stems from an extraordinarily rich epoch of scientific discovery that has revealed the innermost secrets of malignant cells and suggested rational strategies for attacking them. "Until we knew what was wrong with the cancer cell," says oncologist Dr. Bert Vogelstein of Johns Hopkins University, "we couldn't even think about ways of targeting treatment...
...unfold that most people end up dying of ! other causes. Indeed, contrary to popular perception, getting cancer is not at all easy. To begin with, a cell must accumulate mutations not in just one or two genes but in several. In the case of colon cancer, Dr. Bert Vogelstein and his colleagues at Baltimore's Johns Hopkins Oncology Center have shown that a cell must sustain damage to at least three tumor-suppressor genes and one oncogene. The first mutation spurs the growth of the cell, triggering the formation of a benign polyp. Later changes cause the polyp to expand...
...number one cited scientist in the world, according to Science Watch, is Bert Vogelstein, molecular biologist at Johns Hopkins University who has investigated the activity of a tumor suppressor gene...