Word: von
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...Peter Beinart, David Von Drehle and Newt Gingrich note in their stories that are part of our "frozen government" cover package, trust in government is extremely low these days. But trust in government is not by any means a pure virtue; after all, trust in government was high in the 1950s, as some have noted, when the government told schoolchildren they would be safe in the event of a nuclear attack if they put their heads under their desks...
...dose of the medication originally prescribed: patients receiving the highest doses were nearly nine times more likely to overdose than patients on the lowest doses. "The overall risk among people who continued to use opioids was 0.25% per year [or two overdoses per 1,000 people]," says Michael Von Korff, a co-author of the study and senior investigator at the Group Health Research Institute in Seattle, adding that most people involved in the study were on low doses...
...drug misuse or suicide attempts, while others were due to patient error, but the study could not identify exactly what went wrong in all of the cases. Was it the high-prescribed dose alone, or were there other risk factors like illness, escalation of pain or undiagnosed addiction? While Von Korff and Volkow agree that prescription dose is a major contributor to overdose risk, they say better studies are needed to determine the precise causes and consequences. "One would hope that for a treatment regimen that millions of people are using, we'd have large, long-term, well-designed randomized...
...while the risk of opioid addiction in the elderly is low, there are other cautions. A study published in January by Von Korff and colleagues linked high-dose opioid use to a doubling of the risk of broken bones in the elderly. "One-third of these were hip and pelvic fractures," Von Korff says. "These can really be debilitating." The authors speculate that the patients may have been prone to falls caused by dizziness or sedation, side effects of drug treatment that tend to occur early in a new drug regimen or when dosage changes...
...jagged melodics, weaving them into a blindingly rapid melody, as Malone and Barron easily grounded him in a modal swing. On the other hand, his rendition of the 13th century mystical poet Rumi’s “I Like The Sunrise,” set to a Von Freeman sax solo, told a melodic story in which his voice fully rounded out, replicating the searing, insistent quality of repeated notes on a saxophone...