Word: wakes
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...meaning "about one day"). Now, a heart attack depends on the imbalance between increased myocardial oxygen demand (i.e., a greater need for oxygen in your heart) and decreased myocardial oxygen supply - or both. And unfortunately, some functions in the first hours of the day require more myocardial oxygen support: waking and commencing physical activities, the peak of the adrenal hormone cortisol [which boosts blood-pressure and blood-sugar levels] and a further increase in blood pressure and heart rate due to catecholamines (adrenaline and noradrenaline), which show a peak when you wake up. All those factors lead to an increase...
...have to remember that blood coagulation is important in the genesis of what we call thrombi, the blood clots that can block the blood vessels and cut off supply to the heart. When we wake up, platelets, the particles in the blood that make thrombi, are particularly adhesive to the vessels. Usually we have an endogenous system - it's called fibrinolysis - to dissolve the thrombi. But in the morning, the activity of our fibrinolytic system is reduced. So we have a greater tendency to make thrombi that can occlude the coronary vessels. This contributes to further reduction of coronary blood...
...serious demeanor, reflected in his craggy, Lincolnesque features, makes Oakley a poor companion for swapping jokes or, as one old friend put it, ''having him over to the house to get drunk in front of the fire.'' But such intensity has endeared him to colleagues, even those who received wake-up calls alerting them to overnight cables and demanding to know what should be done. ''It's always a little off-putting to get slammed up against the wall at 7:30 in the morning,'' says an admiring Richard Murphy, who worked with Oakley during the Reagan Administration. Oakley...
...satirists - or I think his word was cynics but I think really the word he intended is satirists - are basically disappointed idealists. So you're making people laugh, but you're kind of writing from anger: "It shouldn't be this way! Damn it, why is it like this? Wake up, people!" But as the curdling effect gets more profound, comedy kibitzers kind of do what I would call topical comedy as opposed to satire. And you can see the mechanism of that starting up: the guys are getting their trusty catalogs of "he's so old" jokes that...
...Roberts, CEO of Amro Worldwide, visited South Carolina after the state's tourism board expressed interest in the campaign, and says he toured several gay venues, including largely gay sections of mainstream beaches, in Charleston, Hilton Head Island and Myrtle Beach. "A few people in South Carolina need to wake up to what's going on in their state," he says. "There are more gay bars along that coastal strip than there are in Vegas...