Word: warburgs
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What sounds like yet another version of the Atkins craze is actually based on scientific evidence that dates back more than 80 years. In 1924, the German Nobel laureate Otto Warburg first published his observations of a common feature he saw in fast-growing tumors: unlike healthy cells, which generate energy by metabolizing sugar in their mitochondria, cancer cells appeared to fuel themselves exclusively through glycolysis, a less-efficient means of creating energy through the fermentation of sugar in the cytoplasm. Warburg believed that this metabolic switch was the primary cause of cancer, a theory that he strove, unsuccessfully...
...researchers in Würzburg, the theoretical debate about what is now known as the Warburg effect - whether it is the primary cause of cancer or a mere metabolic side effect - is irrelevant. What they believe is that it can be therapeutically exploited. The theory is simple: If most aggressive cancers rely on the fermentation of sugar for growing and dividing, then take away the sugar and they should stop spreading. Meanwhile, normal body and brain cells should be able to handle the sugar starvation; they can switch to generating energy from fatty molecules called ketone bodies - the body...
...miracle cure in seriously ill patients, who may never benefit from the approach. But the recent findings are difficult to ignore. Robert Weinberg, a biology professor at MIT's Whitehead Institute who discovered the first human oncogene, has long been critical of therapeutic approaches based on the Warburg effect, and has certainly dismissed it as a primary cause of cancer. Nevertheless, he conceded, in an email, for tumors that have been affected by the ketogenic diet in animal models, "there might be some reason to go ahead with a Phase I clinical trial, especially for patients who have no other...
...general economic slowdown, many argue that an interest rate cut is in order to push the economy back on track. But others say the Fed should not bail out a small segment of investors for their “greed and stupidity.” Harvard instructors including Warburg Professor of Economics Robert J. Barro and Baker Professor of Economics Martin S. Feldstein ’61 said they support a lower interest rate, even though such action can push up inflation. “The most important thing [the Fed] does is respond to major financial crises...
...Ramallah, and is now the president of Al-Quds University in Jerusalem. Yet Nusseibeh somehow manages to evade every role into which he might be cast. As a child of Arab nobility, he chooses to marry an Englishwoman. As a Muslim studying Muslim texts, he enrolls in the Warburg Institute in London, a school founded by a Jew. As the chief representative of the Palestinian Liberation Organization in Jerusalem, Nusseibeh continues to state his own opinions in public even though they don’t always align with those of the party. Not surprisingly, the weakest parts of the narrative...