Word: warfarin
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...answer is warfarin, the most prescribed anticoagulant in North America that unites these seemingly disparate phenomenon with two vastly different medical issues: anticoagulation and tuberculosis...
...Warfarin was first discovered during the Great Depression when dairy cattle on a Wisconsin farm suffered excessive bleeding from consuming spoiled sweet red clover hay, which was later found to contain a warfarin-like compound that inhibits blood clotting...
...separate study, researchers at the University of Chicago found that ginseng, which is widely used to boost energy, can sometimes do more harm than good. In 20 volunteers, taking the herb disrupted the effects of the clot-busting drug warfarin, prescribed for millions of heart-attack patients. Because warfarin's dosage must be precise--too little can lead to clotting and too much can cause bleeding--any substance that alters its potency can have serious consequences...
Three years ago in North Carolina, DuPont helped ram through the legislature a bill requiring doctor's approval for the substitution of generics like Barr's warfarin. "We are only concerned about patient safety," says DuPont spokesman Thomas Barry. Some physicians support DuPont's position because they say warfarin is a tricky drug and doses must be carefully calibrated. The implication is that the brand names do a better job of that. But the FDA says the generic version is safe and has admonished DuPont more than once for stoking false fears in its promotion of Coumadin...
...sides worked out a compromise to give immediate approval to most generics. Barr's lobbyists relaxed. Too soon, it turns out. A month ago, an amendment was quietly tacked onto a new bill to help the poor pay for prescriptions. The rider makes it harder to substitute generics like warfarin. Ryan is set to sign the bill...