Word: weight-loss
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...being called a disease? Here, many analysts see the fingerprints of the pharmaceutical industry, which worldwide has more than 20 weight-loss drugs in clinical trials and another 30 in the pipeline. But more on that-and obesity's links to illness-later...
...diet-obsessed world, we all have our own dream of the perfect weight-loss solution: a potato-chip diet, a pill that trims belly fat or, best of all, an exercise that builds lots of muscle with little work. The Power Plate, a new workout machine that looks like a doctor's office scale on steroids, claims to do just that...
When scientists at Sanofi-Aventis took on the challenge of developing a weight-loss drug, they chose an unusual approach. Instead of studying ways to curb the body's natural desire to eat, they decided to home in on the very biological circuits that activate hunger. Even more unorthodox was the craving phenomenon they decided to analyze: the marijuana munchies. If marijuana can trigger the appetite, then perhaps that system could be coaxed into switching...
Rimonabant, the weight-loss compound they developed, is the first drug that manipulates the endocannabinoid system, a network of cells in the brain, the liver and fat tissue that regulates hunger by linking appetite to the body's reward and satisfaction system. Rimonabant reduces food cravings by deactivating the cannabinoid receptors. The drug, to be marketed as Acomplia, is being reviewed by the FDA and will be targeted at those who not only carry excess weight but also harbor unhealthy signs of metabolic disorders such as diabetes and hypertension. In half a dozen clinical trials, the compound helped...
...similar shift in thinking is occurring among weight-loss researchers. For years, their best measure for how dangerous excess weight could be was body mass index (BMI), a formula that combined height and weight. A high BMI meant that you were carrying too much body mass for your height, putting you at risk of developing diabetes, hypertension, heart disease or stroke. The problem, as physicians quickly found out, was that body mass includes not just excess body fat but muscle as well. So fit people with dense muscle mass would consistently register as overweight and unhealthy. That led Dr. Jean...