Word: weighted
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Dates: during 2000-2009
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...probably don't need a scientific study to tell you there's no such thing as a magic weight-loss pill. But a paper published today on BMJ.com shows exactly that: Taking federally approved anti-obesity medications, such as Xenical and Acomplia, leads only to modest weight loss - an extra 6 lbs. to 10 lbs. (2.7 kg to 4.7 kg) a year - and it's not likely to radically trim down bulging waistlines. "People have to understand it's very difficult to lose weight," says lead author Raj Padwal, an assistant professor at the University of Alberta...
...lose 100 pounds or more - they want to look the way they looked in high school. But doctors usually have more modest goals, tempered by their patients' experience - and by concerns about health over vanity. By a doctor's standard, even a 5% to 10% reduction in body weight can make a big difference to a patient's health. On that level, at least, there's little doubt anti-obesity medications can help. The BMJ (formerly the British Medical Journal) paper, a comprehensive review of 30 controlled trials on anti-obesity drugs, showed unambiguously that orlistat (Xenical), sibutramine (Meridia...
...reasons are many. A course of medication can be expensive - hundreds of dollars a year. Drugs also have side effects. Orlistat prompts weight loss by limiting the body's ability to absorb fat, but that can result in oily feces and sometimes incontinence. Sibutramine can raise blood pressure and lead to nausea and insomnia. Rimonabant is associated with an increased risk of psychiatric disorders like depression and anxiety. Still, Padwal says, "I think the main problem is the disappointment." For a lot of patients, the meager results of the medication don't justify their cost and unpleasantness...
...obesity epidemic, meanwhile, is swelling quickly. The World Health Organization estimates that a billion people worldwide are overweight, and 300 million are obese; more than a third of U.S. adults are now obese. So, why is it so hard to lose weight? "It looks very simple: People need to eat less and exercise more," Padwal says. "But if you drill down it's more complicated." Telling a single mother who works full-time that she should take a brisk walk in the inner city after work each day is not the most practical advice - she's unlikely...
...conquest against the Aborigines, systematically denied them any access to the culture of politics right from the moment of settlement in 1788. Aborigines weren't mentioned in the Australian constitution when it took force in 1901. Not until 1962 were they given federal voting rights. The historical weight of discrimination against them is crushing...