Word: weighted
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Dates: during 2000-2009
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Karsenty became intrigued by the relationship between fat and bone after showing in 2002 how leptin, a hormone secreted by fat cells, influences bone formation. Leptin is best known as a regulator of body weight and appetite. Karsenty reasoned that if fat influences bone, then the reverse must be true. And, he says, there was another clue to the relationship: "We were using the observation that obese people are [relatively] protected from osteoporosis...
...some ways it's logical that bone and fat tissue would talk to each other. "Obviously there does need to be some coordination between skeletal growth and body mass," says C. Ronald Kahn, director of the Joslin Diabetes Center at Harvard. "If you carry around extra weight, your bones need to hold up under the extra pressure, so it's not surprising that your bones have a sense of body...
...diet and low-calorie versions of almost every food imaginable, a bit uneasy. "This study simply defies common sense," wrote Dr. Richard Adamson, scientific consultant to the American Beverage Association, in a prepared statement responding to the study. "To suggest that foods and beverages with zero calories contribute to weight gain contradicts the overwhelming body of scientific evidence that supports that they can help you reduce calories and maintain a healthy weight...
...Ramachandran Vasan, lead author of the Framingham study, however, notes, "A zero-calorie drink could produce a metabolic response if it is sweet. It can condition you to develop a preference for sweet things, which can lead to weight gain or metabolic syndrome. So something that is sweet could produce a metabolic effect even if it doesn't have a whole lot of calories...
...course, none of the studies has yet proved that diet foods or beverages actually cause weight gain or heart disease; they have merely found an intriguing association, which scientists are still trying to explain. Well, nobody ever said counting calories was easy...