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...drugs provided relief to 60% to 80% of patients, but they also caused serious side effects, including sluggishness, weight gain and occasionally death from overdose. The ground was ripe for a better pill, and it wasn't long before scientists produced a new, highly targeted class of antidepressants, led by Prozac, which hit the U.S. market in 1987, followed by Zoloft in 1991 and Paxil in 1992. Instead of blanketing a broad range of brain chemicals, the drugs - known as selective serotonin reuptake inhibitors (SSRIs) - zeroed in on one: serotonin, a critical compound that ferries signals between nerve cells. SSRIs...

Author: /time Magazine | Title: Antidepressants | 1/7/2010 | See Source »

...frozen foods sounds less serious; in a 500-calorie entree, after all, 8% adds only 40 calories. That, however, is in a single meal. Over the course of a year, consuming just 5% more than you need in a 2,000-calorie diet can mean a 10-lb. weight gain. "The 18% and 8% figures are just what you need not to lose weight," says Roberts. (See the best pictures...

Author: /time Magazine | Title: Dieters Beware: Calorie Counts Are Frequently Off | 1/6/2010 | See Source »

...book, Roberts reformulated menus to correct for the problem, but there's a big, fattening world out there that isn't taking such remedial steps. Federal regulations are strict about the accuracy of the net weight of a package of prepared food, which must be at least 99% of the advertised weight. When it comes to calories, the count can be a far bigger 20% off. The Federal Government plays no role in checking the calorie claims in restaurants, which means it's up to the states to handle the job - with the predictable patchwork results. "It really...

Author: /time Magazine | Title: Dieters Beware: Calorie Counts Are Frequently Off | 1/6/2010 | See Source »

That seems like a fair requirement. It's hard enough to maintain your weight in the all-you-can-eat buffet that is the modern world. The least the health-conscious should be able to expect is a fair reading of what they're eating - and they can take responsibility from there...

Author: /time Magazine | Title: Dieters Beware: Calorie Counts Are Frequently Off | 1/6/2010 | See Source »

...donors: they caused methyl groups to attach more frequently to the agouti gene in utero, thereby altering its expression. And so without altering the genomic structure of mouse DNA - simply by furnishing B vitamins - Jirtle and Waterland got agouti mothers to produce healthy brown pups that were of normal weight and not prone to diabetes...

Author: /time Magazine | Title: Why Your DNA Isn't Your Destiny | 1/6/2010 | See Source »

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