Word: weightness
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...growing body of research suggests there's another, less visible reason to focus on your gut if you want to lose weight. Scientists led by Andrew Gewirtz at Emory University reveal that your intestines harbor a universe of bacteria - the so-called gut microbiota - that may play an important role in whether your body will store the food you eat as extra pounds. (See pictures of what the world eats...
Gewirtz's team, including researchers at Emory, Cornell University and the University of Colorado at Boulder, became intrigued by the relationship between gut bugs and weight when they noticed that lab mice lacking a certain protein had more of the bugs than other animals and were about 15% heavier. These mice also had a higher level of inflammation, which the authors explain in their paper published online Thursday in Science Express is what may account for the extra weight. Inflammatory signaling can promote a condition called metabolic syndrome, which causes weight gain, high blood pressure and high cholesterol levels...
...insulin compete for the attention of the same intestinal cells; if the cells are busy responding to inflammatory factors, then they are less likely to take up glucose and process it effectively. Such a desensitization to insulin and glucose then leads to the symptoms of metabolic syndrome, such as weight gain, high cholesterol and triglyceride levels and elevated blood pressure - which were all present in the TLR5-deficient mice. (See the top 10 medical breakthroughs...
...TLR5-deficient mice, they too began eating more and developed the same metabolic-syndrome symptoms that their donors had. In other words, the obesity profile of the heavier mice had been transferred to normal mice. "So, applying the logic to humans," says Gewirtz, "we know that to gain weight and become obese, [it] requires you to eat more. The question is, Why do people eat more? Our results suggest that one reason people might be eating more is because of changes in their intestinal bacteria...
...marriage licenses had been processed (of which almost all were for same-sex couples). "It's like a weight has been lifted off everyone," Michaud said. "You look at people's faces, and there's genuine happiness...