Word: weindruch
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...University of Wisconsin at Madison, gerontologist Richard Weindruch studies deprivation, like Sinclair, but has a different idea about why calorie restriction works. He has been comparing calorie-restricted rhesus monkeys with unrestricted ones and has found striking differences. The CR monkeys have shown no evidence of diabetes, for example, while it affects about half of normal monkeys. Only four of his CR monkeys, moreover, have died from age-related diseases--half the rate of the control group. He believes the explanation lies in the complex activities of fat cells. The CR monkeys have much less body fat, and that--just...
Calorie restriction has its downside, though, and it's not just hunger. Weindruch's monkeys experience changes in bone density, and other labs have reported changes in libido, menstrual cycles and body temperature in calorie-restricted monkeys. And Sinclair's worms and flies suffer from loss of appetite and fertility. Researchers hope to create drugs based on resveratrol or on the genetic research that would avoid those pitfalls...
...careful about generalizing extensively from observations in the roundworm," said Dr. Richard Weindruch, who studies aging in mice at the University of Wisconsin. "It's not clear to what extent these findings represent the situation in mammals...
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