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...AIDS (for which Ho was named TIME's Person of the Year in 1996). But in recent years, the center has suffered a series of setbacks, including a scientific paper that required a partial retraction, and the departure of key scientists. These challenges have some in the field wondering whether ADARC - and its golden-boy director - are on the verge of the next big breakthrough in AIDS or are wandering down yet another detour in the long and maddening fight against the disease...

Author: /time Magazine | Title: David Ho: The Man Who Could Beat AIDS | 1/25/2010 | See Source »

...inevitably found a way to evade them. So while the agent seemed to reduce the burden of virus in the blood up to 90% in patients with full-blown AIDS, no one knew how long the viral standoff would last. The company's leaders wanted Ho's opinion on whether the agent was worth developing further...

Author: /time Magazine | Title: David Ho: The Man Who Could Beat AIDS | 1/25/2010 | See Source »

...working with monkeys to test whether ibalizumab can head off infection not just with the notoriously weaker lab strains of HIV but also but with naturally circulating strains as well. The idea is to hit the antibody with the most potent HIV around, so if the strategy doesn't work, Ho can shut down the project, before it gets too far along...

Author: /time Magazine | Title: David Ho: The Man Who Could Beat AIDS | 1/25/2010 | See Source »

...every White House tenure when you can practically see the President walk away from everyone he's known, everyone he's been, because he now has thoughts and fears and hopes that no one else can fathom. Franklin Roosevelt faced a collapsing economy. Harry Truman had to decide whether to drop the atom bomb. John F. Kennedy found himself invading Cuba. I wonder when Obama's moment came, as he splashed into office through a sea of red ink, ended his first year with a national-security nightmare and in between set out to pass a health care reform bill...

Author: /time Magazine | Title: Obama After One Year: The Loneliest Job | 1/25/2010 | See Source »

...real loneliness of the office does not come from old friends preening and new ones pretending. It comes from the nature of the job. Dwight D. Eisenhower recalled how as a general, before D-Day, he had to decide whether to send two paratroop divisions into a sector where 9 out of 10 would probably be slaughtered. He eventually decided the troops were essential to the mission, and for years after that, he said, "I felt that only once in a lifetime could a problem of that sort weigh as heavily on a man's mind and heart." Then...

Author: /time Magazine | Title: Obama After One Year: The Loneliest Job | 1/25/2010 | See Source »

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