Word: woodwarding
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...Bruce A. Woodward '52, Douglas M. Saxe '53, and Phelps Hunt '48 put through a call to Governor Wright late last night. Woodward spoke to the Governor for three minutes, arguing that an innocent man was being murdered with the full knowledge...
...producing it is through an intricate chemical process of 30-odd steps starting with cattle bile. And the yield is so small that several dozen head of cattle are needed to produce one average daily dose for one patient. But last week Harvard's Professor Robert B. Woodward announced that he had reached the first milestone on the road to making synthetic cortisone from simple chemicals...
...Woodward started out with orthoto-luidine, an oily liquid extracted from coal tar, whose molecule has one six-carbon ring and one methyl (CH3) group. Step by step he attached more atoms, carefully choosing his reactions so that the atoms would fall in the proper places. After some 20 laboratory steps, his 22 Ibs. of original raw materials were reduced to 1/28 oz. of a genuine steroid. The compound's molecule has the steroid nucleus with an oxygen atom attached at one end and a carbome-thoxy (C02CH3) group at the other...
...Chemist Woodward emphasized the fact that his new substance is not yet cortisone. He must add another oxygen atom in the proper spot, and must exchange his carbomethoxy group for a dihydroxyacetone sidechain. In the process it will also be necessary to alter the double bonds that now join some of the atoms in his steroid (see diagram). But Chemist Woodward's cautious colleagues agree that the toughest part of the job seems to be over...
...Woodward cautioned that no medically active steroids have been synthesized as yet and that the processes already developed may not prove commercially practicable...