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...increased risk of developing the disease. That risk shot up to over 900% in patients who had the genetic variants and a family history, accounting for nearly half of the prostate cancer cases in the study. "We've never seen this before," says Dr. Jianfeng Xu of Wake Forest University School of Medicine and one of the authors of the study conducted jointly with researchers at Sweden's Karolinksa Institute and Johns Hopkins Brady Urological Institute, among others. Because the variants are common in the general population and their collective association with cancer is so strong, Xu says his findings...
...Xu hasn't wasted any time taking his own advice. He and a colleague at Wake Forest have already spun a private business around the study's results - Proactive Genomics, which, like many similar companies that have sprung up recently, will offer a personal genetic test. This one, however, says Xu, will be the world's first genetic screen for a specific disease. To assess cancer risk, patients and doctors currently rely on physical symptoms, age, race, family history and PSA screens - tests that measure blood levels of prostate-specific antigens, which are produced in high amounts by an unhealthy...
...While Xu's test may help identify at-risk patients more accurately and earlier, what it won't do is tell patients - or doctors - who's at risk for developing aggressive, life-threatening disease. In fact most prostate cancer cases in the United States never become lethal: 99% of men diagnosed with prostate cancer - the vast majority of whom are over 65 - survive at least five years, according to the American Cancer Society, and many die with the disease, not because of it. Still, prostate cancer does kill some 30,000 men a year in U.S. Learning more about genetic...
...visitors. In its first year, Hong Kong's Disneyland, which opened in September 2005, had about 15,000 visitors per day, about 40% of its capacity. And guests have complained about long lines and high prices at the amusement park. "It wasn't what I hoped for," says Alex Xu, who recently visited the park from Beijing. "I'd rather save my money and go to the real Disney World someday...
Modest Mouse. If you’re going to travel back in time at all, ditch the melodrama and take up your former quirkiness—I’ll be waiting for the return of the crow suit. —Denise J. Xu...