Word: yamanaka
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...Yamanaka Ryokan Try Tokyo's best kaiseki-style Chinese restaurant and sleep on a fluffy futon at this little-known gem, just five minutes by taxi from the express train to Narita. Tel: (81-3) 3821-4751, 4-23-1 Ikenohata. (See Time.com/Travel for city guides, stories and advice...
...Japanese scientist Shinya Yamanaka first induced stem cells from adult mouse fibroblasts—cells most commonly found in connective tissue—by using viruses to insert four genes into the fibroblasts. These genes worked to reprogram the cells into pluripotent stem cells...
...Robert Lanza, chief scientific officer at Advanced Cell Technology (ACT), reported today in the journal Cell that his team has created stem cells using human skin cells and four proteins. The innovation builds on the breakthrough discovery in 2006 by Shinya Yamanaka, who similarly coaxed human skin cells to revert to a pristine, embryonic state by introducing four key genes into the cells, piggybacked on viruses. However, some of those genes are known to cause cancer, which made Yamanaka's stem cells - known as induced pluripotent stem cells, or iPS cells - unsuitable for human use. (See a graphic explaining...
Until now, no one has been able to create iPS cells without using viruses and genes. But Lanza and his team found a way around both: the researchers isolated the proteins made by the same genes Yamanaka used and "tagged" them with a message that allowed the proteins to slip easily into the cell. Yamanaka's method, on the other hand, relied on using viruses to ferry genes into the skin cell...
...group says the iPS cells generated using their method are equivalent to those made using Yamanaka's strategy. In fact, they seem to flourish more robustly than the traditional iPS cells, at least in lab tests that involve regrowing certain cells found in the retina. This could lead to a potential treatment to replace damaged eye cells in conditions such as retinitis pigmentosa or macular degeneration...