Word: yuan
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Dates: during 2000-2009
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...past research, Yuan has worked to understand the roles of proteins and genes controlling ‘apoptosis,’ or cell suicide. This has repercussions for chronic neurodegenerative diseases such as Alzheimer’s and Huntington’s, which are caused by excessive apoptosis in the brain...
...project for which Yuan received funding will carry this work further, into work on the influences of aging on neurodegenerative diseases...
...Professor Yuan] is trying to connect two different fields, aging and neurodegenerative diseases,” said Caroline H. Yi, a graduate student at Yuan’s laboratory. “Her hypothesis is that the aging process is somehow promoting the toxicity of mutant proteins in neurodegenerative diseases...
Michael S. Boyce ’05, who just finished his Ph.D. under Yuan, said her research team hopes to find chemicals that will inhibit the proliferation of neural degeneration...
...Yuan is perhaps best known for research showing that the abnormal repetition of a protein called polyglutamine in cells led to an overactivation of the enzyme caspase-8—which is critically involved in apoptosis. These results suggested that the mutant protein helped accelerate cell death and degeneration in neural diseases...