Word: zebrafish
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...ankle out, but develop in a fanlike progression that runs from the smallest digit to the largest. In Geneva, Duboule and his colleagues tracked the activity of four Hox genes in the budding feet of embryonic mice and found precisely this pattern. By contrast, studies showed that in the zebrafish, the Hox genes switch off earlier, perhaps to ensure that a flexible fin ray (useful for swimming) will form in the place of feet. Duboule speculates that if these genes could be tricked into staying on just a bit longer, the fins of the zebrafish might sprout appendages suggestive...
Duboule concedes that "this is not even a real hypothesis," just a hunch, and that testing it will not be easy. One problem, contends Harvard's Tabin, is that Duboule and his colleagues studied "the wrong fish." Zebrafish are prolific and easy to raise under laboratory conditions, but they are advanced in evolutionary terms. A study of more primitive sea life, such as sharks or sturgeon, might yield greater amounts of evolutionary information; even better subjects would be lungfish and coelacanths, mysterious, nearly extinct creatures that lurk in the ocean depths and are the living fish closest to the fishlike...
Fulwiler was one of about six researchers in Gilbert's lab studying zebrafish as a model for early development of genes. Harvard accused Fulwiler of changing data in his laboratory notebook to make it appear an experiment with the fish's genes had worked better than it actually...
Fulwiler was one of about six researchers in Gilbert's lab studying zebrafish as a model for early development of genes. Fulwiler allegedly changed data in his laboratory notebook to make it appear as if an experiment with the fish's genes had worked better than it actually...
...Carl E. Fulwiler, research associate in biology, said he had "no response" to a charge that he altered data for an experiment that was part of Gilbert's zebrafish research project. The allegation is under investigation by the standing faculty committee on professional conduct, sources said...