Word: zebroski
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Dates: during 1990-1999
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Some days the arthritis pain would get so bad that Sylvia Zebroski, 51, of Stamford, Conn., couldn't sleep. Aspirin worked for a while, but then she developed stabbing pains in her stomach. She switched to naproxen, which, like aspirin, is a so-called nonsteroidal anti-inflammatory drug, or NSAID. Same story. "I took myself off naproxen and went to my doctor in tears," she recalls. He put her on a new experimental drug, and this time, no arthritis pain--and no stomach pain. Says Zebroski: "It's made all the difference in the world...
...drug that changed Zebroski's life is just one of a new class of medications that could radically alter the way in which pain is treated in the U.S. Each year 7,600 Americans die from internal bleeding caused by long-term use of NSAIDs. The new drugs, called COX-2 inhibitors, relieve pain just about as well as aspirin and its cousins but seem to have no serious side effects. With visions of $5 billion or more in potential sales over the first five years, drug companies are racing to get their own versions of these superaspirins to market...