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...synapses. The result, hopefully, is that the patient begins to feel better within a few weeks. But how solid is the chemical-imbalance model of depression? That depends on whom you ask. The drug companies present it as fact. On its website, Pfizer, maker of the blockbuster SSRI sertraline (Zoloft), asserts that antidepressants "work by correcting the chemical imbalance in your brain." The Australian mental health lobby group beyondblue is slightly more circumspect in its literature, saying "severe depression appears to be associated with a reduction in the chemicals of the brain." Depression comes in various types and shouldn...

Author: /time Magazine | Title: Bitter Pills | 11/14/2005 | See Source »

WHAT DO YOU TAKE NOW? Zoloft...

Author: /time Magazine | Title: 10 Questions for Mike Wallace | 10/23/2005 | See Source »

...electrical currents in their brain? "You have to remember the brain is both an electrical and a chemical organ," says Dr. Mark George, a psychiatrist at the Medical University of South Carolina who is investigating magnetic stimulation as a treatment for depression for the NIMH. Drugs like Prozac and Zoloft address chemical imbalances, but that's only part of the problem. Electroconvulsive therapy, despite its troubling side effects, is still one of the most effective treatments available for severe, unrelenting depression...

Author: /time Magazine | Title: Resetting the Brain | 3/14/2005 | See Source »

CONVICTED. CHRISTOPHER PITTMAN, 15, teenager who claimed taking the antidepressant Zoloft led him to shoot his grandparents in their bed in 2001; on two counts of murder; in Charleston, S.C. Though jurors rejected the Zoloft defense, they agonized over trying Pittman, who was 12 when he committed the crime, as an adult. He was sentenced to the minimum term of 30 years in prison...

Author: /time Magazine | Title: Milestones Feb. 28, 2005 | 2/20/2005 | See Source »

...almost a century, the U.S. Food and Drug Administration (FDA) has endured its share of rough patches. But "rough patch" hardly begins to describe all the bad news that has battered the agency over the past few months, from the possible suicide risks with antidepressants like Prozac, Paxil and Zoloft to the cardiac risks of pain-killers like Vioxx, Celebrex and Bextra. Americans depend on the FDA to carefully weigh the benefits and risks of all drugs before approving them, but the agency has had trouble lately shaking the growing perception, justified or not, that it has been working harder...

Author: /time Magazine | Title: Can the FDA Heal Itself? | 2/20/2005 | See Source »

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